Steroids and derivatives
Medchemexpress LLC Estradiol-d5 | 221093-45-4 | 99.1% | 1 MG
Estradiol-d5 is a deuterium-labeled form of Estradiol. Estradiol is a steroid sex hormone crucial for maintaining fertility and secondary sexual characteristics in females. It upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by techniques such as NMR, GC-MS, or LC-MS.
- Deuteration can impact the pharmacokinetic and metabolic profiles of drugs.
- Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules for quantitation during the drug development process.
Medchemexpress LLC Estradiol 3-methyl ether | 1035-77-4 | 99.9% | 286.41 | 25 MG
Estradiol 3-methyl ether is a synthetic estrogen. It can disrupt microtubule networks in V79 cells with an EC50 of 9 μM and inhibits cell proliferation. Estradiol 3-methyl ether has also been shown to decrease serum cholesterol levels and increase body weight loss, indicating feminizing activity in an HFD murine model.
- Synthetic estrogen
- Disrupts microtubule networks in V79 cells (EC50 of 9 μM)
- Inhibits cell proliferation
- Decreases serum cholesterol levels
- Increases body weight loss in HFD murine models
Cayman Chemical EstradIol CypIonate 5g
A synthetic estrogen; reduces estrogen-depletion induced spikes in basal tail temperature in ovariectomized wild-type, ERα-/-, and ERβ-/- mice at 0.1 mg/kg per day; increases the rate of pregnancy in cows induced to ovulate small dominant follicles; reduces edema and articular joint neutrophil infiltration in an ovariectomized mouse model of zymosan-induced arthritis
Medchemexpress LLC Estradiol 3-sulfamate | 172377-52-5 | 351.46 | 50 MG
Estradiol 3-sulfamate is a potent, long-acting, and orally active steroid sulfatase inhibitor. It inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM. The compound is readily transformed and absorbed in the gut into its oxidative metabolite, EMATE, demonstrating potent and long-acting STS inhibition.
- Potent, long-acting, and orally active steroid sulfatase inhibitor.
- Inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM.
- Increased estrone sulfatase inhibitory activity with specific halogen moieties.
- Readily absorbed and transformed in the gut into its oxidative metabolite, EMATE.
- Both compounds demonstrate potent and long-acting STS inhibition.
Alkali Scientific Digitonin, Water Soluble, 500 Milligrams
Digitonin is a water-soluble compound used primarily in membrane permeabilization for research applications. Available in a 500mg format, Digitonin is widely used in cell biology to permeabilize cell membranes, allowing researchers to study intracellular components or deliver compounds directly into cells. It is particularly useful in protein extraction, cellular signaling studies, and in assays that require the breakdown of membrane integrity without damaging the cells entirely. This high-purity product facilitates effective permeabilization while maintaining cellular viability, making it essential for research on cellular processes, membrane proteins, and intracellular interactions.
Cambridge Isotope Laboratories Estradiol (16 16 17-D3 98%) CP 95% 1 mg
Estradiol (16 16 17-D3 98%) CP 95% 1 mg
Apexbio Technology LLC Ethinyl Estradiol 57-63-6 500mg
Ethinyl Estradiol (57-63-6) is a small-molecule estrogen receptor agonist targeting intracellular estrogen receptors It is designed to activate these receptors thereby regulating transcription of estrogen-responsive genes and influencing reproductive biology and cell proliferation pathways Ethinyl Estradiol exerts its biological activity primarily through direct binding to estrogen receptors leading to the modulation of endocrine-regulated mechanisms Based on these pharmacological properties Ethinyl Estradiol holds research potential in studies of receptor-mediated responses endocrine regulation mechanisms synthetic hormone interactions drug interactions contraceptive mechanisms and hormone-dependent physiological processes
Medchemexpress LLC Estradiol-d2-1 | 3188-46-3 | 1 MG
Estradiol-d2-1 is a deuterium-labeled Estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. It upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Incorporates stable heavy isotopes into drug molecules
- Has potential to affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Estradiol valerate | 979-32-8 | >99.9% | 25 MG
Estradiol valerate is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents. It is for research use only and not sold to patients. It is also identified as a reproductive toxicant and estrogenic chemical in both male and female fish.
- Molecular weight: 356.50
- Formula: C23H32O3
- Appearance: Solid, white to off-white
- Shipping: Room temperature in continental US
- Storage: Powder at -20°C for 3 years, 4°C for 2 years; in solvent at -80°C for 2 years, -20°C for 1 year
- Solubility in DMSO: ≥ 50 mg/mL (140.25 mM)
- Solubility in ethanol: 12.5 mg/mL (35.06 mM)
- Insoluble in H2O
- Target: Estrogen Receptor/ERR
Cayman Chemical EstradIol 3 DGlucuronIde 25mg
A non-cholestatic regioisomer of E217G that acts as a substrate for MRP2, competing with E217G for MRP2-mediated transport (IC50 = 14.2 µM)
Cayman Chemical 2-bromo 17-EstradIol 50mg
A synthetic steroid and inhibitor of estrogen 2-hydroxylase; inhibits estrogen 2-hydroxylase in rat liver microsomes at 50 and 100 µM; prevents estrogen-induced inhibition of apomorphine-induced climbing behavior in mice at 5 mg/kg
Apexbio Technology LLC Estradiol Cypionate 313-06-4 10mM (in 1mL DMSO)
Estradiol cypionate (313-06-4) is a small-molecule agonist targeting estrogen receptors (ER) It is designed to activate ER thereby modulating downstream ER-mediated gene transcription and signaling pathways and regulating processes such as vascular homeostasis Estradiol cypionate exerts its biological activity primarily through ER agonism influencing gene expression and inhibiting endothelin-1 (ET-1) synthesis via ER-dependent mechanisms Based on these pharmacological properties estradiol cypionate holds research potential in elucidating estrogen receptor mechanisms and studying estrogen-associated vascular and endocrine systems and disorders
Medchemexpress LLC Estradiol (Standard) | 50-28-2 | MFCD00003693 | 100.0% | 25 MG
Estradiol (Standard) is an analytical standard of Estradiol, a major female sex hormone and steroid hormone. Intended for research and analytical applications, it can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. This compound is useful for research in cancers, neurodegenerative diseases, and neural tissue engineering.
- Analytical standard grade
- Reference standard for assays
- Utilized in qualitative, quantitative, and methodological research experiments
- Applicable in techniques such as HPLC, GC, and MS
- Supports research in cancers, neurodegenerative diseases, and neural tissue engineering
- Up-regulates neural markers of human endometrial stem cells
- Promotes neural differentiation
Medchemexpress LLC β-Estradiol 17-acetate | 1743-60-8 | 99.9% | 1 ML
β-Estradiol 17-acetate is a metabolite of estradiol, designed for research use only in laboratory settings. It is provided for chemical synthesis and intended for use by experienced personnel in appropriately equipped facilities.
- Available in powder and pre-dissolved solution formats.
- Stable under recommended storage conditions, with specific guidance for powder and solvent forms.
- Highly soluble in DMSO for in vitro applications.
- Features established protocols for in vivo solubility using various solvent systems.
- Molecular formula C20H26O3 and molecular weight of 314.42.
- Typically appears as a white to off-white solid with a melting point of 119°C.
Medchemexpress LLC Alpha-Estradiol (Standard) | 57-91-0 | 99.93% | 25 MG
Alpha-Estradiol (Standard) is the analytical standard of Alpha-Estradiol, intended for research and analytical applications. It is a weak estrogen and a 5α-reductase inhibitor used as a topical medication in the treatment of androgenic alopecia.
- Reference standard supplied assay
- Commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS